HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetic Acid → HCID 131715814, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetic Acid | HCID 176 | — |
| Edukt | Water | HCID 962 | — |
| Edukt | (2S)-2-amino-5-(((tert-butoxy)carbonyl)amino)pentanoic acid | HCID 6993436 | — |
| Edukt | Diethylether ethylacetate | HCID 21584169 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | HCID 131715814 | HCID 131715814 | 88% |
Reaktionsschritte
9.3 g of H-Orn(Boc)-OH, 5.0 g of the N-hydroxysuccinimide ester of acetic acid and 4.1 ml of NEM in 50 ml of DMF and 10 ml of H2O are allowed to react at room temperature for 3 days. The solvent is evaporated off in vacuo, and the residue is chromatographed on silica gel (system 4). 9.6 g of Ac-Orn(Boc)-OH (yield: 88%) readily crystallize from EA/diethyl ether. MS (FAB): 275 (M+1).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04797471 |
| Quelldatensatz | uspto-grants-1989_01 |
| ORD ID | ord-cc0225c8c0df4c3c8555c5cce744e32b |
| Quellennotiz | uspto-grants-1989_01 |