Dicyclohexylcarbodiimide → HCID 131715815, compound

Participants

Reaction Conditions

Reaction Steps

5.6 g of Ac-Pro-Orn(Boc)-OH, 5.0 g of the tosylate of H-Gly-OBzl and 2.0 g of HOBt are dissolved in 50 ml of DMF, cooled to 0° C., and 1.9 ml of NEM and 3.4 g of DCC in 5 ml of DMF are added. The mixture is stirred at 0° C. for one hour, and at room temperature overnight. After the urea has been removed by filtration, the solvent is removed by evaporation in vacuo, and the residue is chromatographed on silica gel (system 4). 6.1 g (yield: 79%) of Ac-Pro-Orn(Boc)-Gly-OBzl remain as an oil. Rf (system 4)=0.75; MS (FAB): 519 (M+1).

Provenance & Evidence