4-[4-(6-Chloropyrazin-2-yl)piperazin-1-yl]butan-1-amine → Hexahydro-3-[4-[4-(6-chloro-2-pyrazinyl)-1-piperazinyl]butyl]-1,5-methanocyclopent[d]azepine-2,4(1H,3H)-dione

Participants

Reaction Steps

The title compound was prepared from 4.58 g (25.4 mmoles) of bicyclo[3.3.0]-octane-2,4-dicarboxylic anhydride and 7.10 g (26 mmoles) of 1-(4-aminobutyl)-4-(6-chloro-2-pyrazinyl)-piperazine following the procedure in Example 1. 7.24 g of the hydrochloride salt was isolated as the one-quarter hydrate, m.p. 223°-225° C.

Provenance & Evidence