HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2291675Generated: October 26, 2026
Dimethylformamide → Isobutyl 4-benzylidene-2,5-dioxo-1-imidazolidinepropionate
https://huagongshe.com/reaction/2291675
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Isobutyl acrylate | HCID 7819 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 5-Benzylidenehydantoin | HCID 97857 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Isobutyl 4-benzylidene-2,5-dioxo-1-imidazolidinepropionate | HCID 54303283 | 81.1% |
Reaction Steps
20 g (0.106 mol) of benzalhydantoin, 14.9 g (0.117 mol) of isobutyl acrylate and 1.2 g (0.02 mol) of potassium hydroxide were added to 150 ml of DMF, and the mixture was stirred at 110° C. for 2 hours. After cooling, the reaction solution was added with 300 ml of toluene and crystallized. The crystals were filtered out and dried to obtain 27.2 g of isobutyl 4-benzylidene-2,5-dioxo-1-imidazolidinepropionate (yield: 81%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04797493 |
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| Source dataset | uspto-grants-1989_01 |
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| ORD ID | ord-e70ac30486cc44e49af36f1236cdd6a5 |
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| Source note | uspto-grants-1989_01 |
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