Isobutyl 3,4-epoxybutyrate → Oxiracetam

Participants

Reaction Steps

1.3 g of 1,4-diazaspiro[4,5]decan-2-one ((5); R4 +R5 =--(CH2)5 --) (8.4 mmoles) are heated and stirred with magnetic stirring, with 1.5 g 2-methylpropyl 3,4-epoxybutanoate ((4), X=isobutyl) (9.5 mmoles) up to 110° (external temperature) for 24 h. The mixture is cooled, and the dark mass obtained is washed with 10 ml boiling ethyl acetate. This is decanted, and the solid obtained is crystallised from methanol to give oxiracetam as a crystalline white powder, m.p. 167°-70° C.

Provenance & Evidence