HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyl 3,4-epoxybutyrate → Oxiracetam
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyl 3,4-epoxybutyrate | HCID 5463767 | — |
| Reactant | 1,4-Diazaspiro[4.5]decan-2-one | HCID 13125039 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Oxiracetam | HCID 4626 | — |
Reaction Steps
0.5 g 2,2-dimethyl-4-imidazolidinone ((5); R4 =R5 =CH3) (4.38 mmoles) are heated at 115° C. (external temperature) for 12 h with stirring by a magnetic stirrer, with 0.57 g ethyl 3,4-epoxybutanoate ((4); X=C2H5) (4.38 mmoles). The mixture is cooled, taken up with methanol and filtered. Oxiracetam is obtained, m.p. 167°-70° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04797496 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-2bd7cad06e214dc4975172185fc10cdd |
| Source note | uspto-grants-1989_01 |