HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 4,4,5,5,5-Pentafluoro-3-oxopentanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Propanoic acid, 2,2,3,3,3-pentafluoro-, ethyl ester | HCID 67928 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | 4,4,5,5,5-Pentafluoro-3-oxopentanenitrile | HCID 15613821 | 77.8% |
Reaction Steps
Acetonitrile (4.1 g, 0.10 mole), ethyl pentafluoropropionate (9.61 g, 0.05 mole) and a solution of n-butyllithium in n-hexane (70 ml, 0.11 mole) were reacted as the procedure illustrated in the preceding Preparation 1 to give 7.28 g (77.8%) of the title compound. The resulting compound was dissolved in CDCl3 to measure NMR, the ratio of the keto form/the enol form was found to be 26/74, m.p. 47°-54° C. (deliquescence), b.p. 69°-71° C./18 mmHg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04797492 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-664ea92d70a342379236b64dc64317b8 |
| Source note | uspto-grants-1989_01 |