HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(Trifluoromethyl)-1,2-oxazol-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 4,4,4-Trifluoro-3-oxobutanenitrile | HCID 13843540 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(Trifluoromethyl)-1,2-oxazol-5-amine | HCID 13913996 | 13.8% |
Reaction Steps
Trifluoroacetoacetonitrile (1.37 g, 0.010 mole), hydroxylamine hydrochloride (0.69 g, 0.010 mole), ethanol and water were heated under reflux for 3 hours. After the addition of hydrochloric acid (1.21 g, 0.012 mole), the mixture was further heated under reflux to give the title compound (0.21 g, 13.7%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04797492 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-174030b76d364d9e86edef6a6abb14ae |
| Source note | uspto-grants-1989_01 |