HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyurea → 3-(Trifluoromethyl)-1,2-oxazol-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyurea | HCID 3657 | — |
| Reactant | 4,4,4-Trifluoro-3-oxobutanenitrile | HCID 13843540 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(Trifluoromethyl)-1,2-oxazol-5-amine | HCID 13913996 | 11% |
Reaction Steps
Trifluoroacetoacetonitrile (5.12 g, 0.030 mole), hydroxyurea (2.51 g, 0.033 mole) and methanol were heated under reflux for 150 hours to give the title compound (0.50 g, 11.0%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04797492 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-8a15cfda7feb4ac39689a0103f82fb35 |
| Source note | uspto-grants-1989_01 |