Boron tribromide → N-{4-[(4-hydroxyphenyl)(3,3,5,5-tetramethylcyclohexylidene)methyl]phenyl}acetamide

Participants

Reaction Conditions

Reaction Steps

N-{4-[[4-(methyloxy)phenyl](3,3,5,5-tetramethylcyclohexylidene)methyl]phenyl}acetamide (57) (0.27 g, 0.69 mmol) was dissolved in CH2Cl2 (25 mL). The mixture was cooled to −10° C. in an ice-acetone bath. To this solution was added 1 M BBr3 in CH2Cl2 (2.1 mL, 2.07 mmol). The reaction mixture was stirred at −10° C. to 0° C. for 3 h, then poured onto ice, extracted with EtOAc (2×60 mL). The combined organic extract was washed with water, brine and dried over Na2SO4. Upon concentration and trituration with 1:1 hexanes:CH2Cl2, compound 58 was obtained as a light brown solid (0.10 g, 39%). mp 118-121° C. 1H NMR (400 MHz, DMSO-d6): δ 0.85 (s, 6H), 0.86 (s, 6H), 1.23 (s, 2H), 1.87 (s, 2H), 1.89 (s, 2H), 1.98 (s, 3H), 6.64 (d, J=8.3 Hz, 2H), 6.89 (d, J=8.5 Hz, 2H), 7.00 (d, J=8.5 Hz, 2H), 7.44 (d, J=8.4 Hz, 2H), 9.24 (s, 1H), 9.84 (s, 1H); LCMS (ES): m/z 378 (M+H)+, 376 (M−H)−. Anal. Calcd for C25H31NO2.1/3H2O: C, 78.29; H, 8.32, N, 3.65; Found: C, 78.33; H, 8.26, N, 3.62.

Provenance & Evidence