HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetate → HCID 178445999, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetate | HCID 84468 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | N-carbobenzyloxyalanine | HCID 736104 | — |
| Reactant | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Reactant | HCID 178446001 | HCID 178446001 | — |
| Reactant | HCID 178446002 | HCID 178446002 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178445999 | HCID 178445999 | — |
Reaction Steps
From 715 g of trifluoroacetate of H-Arg(NO2)Ala-Arg(NO2)-Leu-NH2 in solution in 4 l of DMF and 233 g of Z-Ala-OH and 500 g of BOP employing the same technique as the one described in I-2 (and without treatment in that case by TFA-CH2Cl2), 612 g of Z-Ala-Arg(NO2)-Ala-Arg(NO2)Leu-NH2 (76%) are obtained, after recrystallization in the DMF-ether mixture, in the form of a white pulverulent solid, monitored by TLC and NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04797469 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-51950624b03246dcb0aa09dbf67d136b |
| Source note | uspto-grants-1989_01 |