Sulfuric Acid → HCID 13730924, compound

Participants

Reaction Steps

To 6.4 g of 2-[5-(1-hydroxy-1-methylethyl)-2-pyridyl]-4-isopropyl-4-methyl-2-imidazolin-5-one is added with stirring and cooling (ice) 30 ml concentrated sulfuric acid. The mixture is stirred at room temperature for a further 30 minutes, then poured onto 100 ml ice. The pH of this mixture is adjusted to 4 with concentrated ammonium hydroxide and extracted with 3×200 ml ether. The combined extracts were washed with saturated brine, dried and concentrated to give 5.71 g yellow solid. Recrystallization from ether-hexane gave analytically pure 2-(5-isopropenyl-2-pyridyl)-4-isopropenyl-4-methyl-2-imidazolin-5-one, mp 123°-125° C.

Provenance & Evidence