Aniline → HCID 2797953, compound

Participants

Reaction Steps

To a stirred solution of dimethylacetylenedicarboxylate (DMAD, 0.10 mol) in 50 ml of ethylenedichloride (EDC), is slowly added a solution of aniline (0.10 mole) in 15 ml of EDC. The temperature of the reaction mixture is maintained below 30° C. and stirring is continued for about one hour until the reaction is essentially complete. The toluene is then removed under vacuum to afford the dimethyl 3-phenylaminobut-2-ene-dioate.

Provenance & Evidence