Trifluoroacetic acid → HCID 14107782, compound

Participants

Reaction Steps

Lysergol was prepared as described by Stoll et al., Helv. Chim. Acta 1949, 32, 1949. Following procedures essentially as described in Example 1, a mixture of 7 ml of TFA, 1.78 g (15.28 mmol) triethylsilane and 0.508 g (2.0 mmol) of lysergol was stirred for 3 hours and gave 0.13 g of the title compound (25%) following column chromatography (50 g silica gel, chloroform:methanol: ammonium hydroxide eluent, 8:2:0.5%), mp. 177°-178.5° C.

Provenance & Evidence