Triethylsilane → HCID 14107790, compound

Participants

Reaction Steps

(5β,8β)-9,10-didehydro-6-methyl-8-(methylthiomethyl)ergoline was prepared according to the method of Kornfeld et al. in U.S. Pat. No. 3,901,894. Following procedures essentially as described in Example 1, a mixture of 20 ml of TFA, 5.24 g (45.1 mmol) of triethylsilane and 3.1 g (10.9 mmol) of (5β,8β)-9,10-didehydro-6-methyl-8-(methylthiomethyl)ergoline was stirred for 5 hours and gave 1.34 g of the title compound (42%) after HPLC and recrystallization from a mixture of diethyl ether/hexane, mp. 93°-97° C.

Provenance & Evidence