Triethylsilane → HCID 14107793, compound

Participants

Reaction Steps

(5β,8β)-9,10-didehydro-6-methylergoline-8-acetonitrile was prepared according to the method of Troxler et al., Helv. Chim. Acta 1968, 51, 1060. Following procedures essentially as described in Example 1, a mixture of 10 ml of TFA, 1.82 g (15.7 mmol) of triethylsilane and 1.0 g (3.8 mmol) of (5β,8β)-9,10-didehydro-6-methylergoline-8-acetonitrile was stirred overnight and gave 0.37 g of the title compound (37%) after recrystallization from a mixture of ethyl acetate/diethyl ether, mp. 180°-182° C., [α]589nm +14° (c=0.46 percent, pyridine).

Provenance & Evidence