Trifluoroacetic acid → HCID 14107796, compound

Participants

Reaction Steps

(5β,8β)-9,10-didehydro-6-methyl-8-(phenylthiomethyl)ergoline was prepared as described by Kornfeld et al. supra. Following procedures essentially as described in Example 1, a mixture of 12 ml of TFA, 3.0 g (26.1 mmol) of triethylsilane and 2.32 g (6.7 mmol) of (5β,8β)-9,10-didehydro-6-methyl-8-(phenylthiomethyl)ergoline was stirred overnight and provided 0.81 g of the title compound (35%) following HPLC (5% methanol/methylene chloride), mp. 54°-58° C.

Provenance & Evidence