Sodium Hydroxide → HCID 14154748, compound

HRID 2291833Notes

Reaction equation

HRID 2291833 reaction equation
C([S:4][C@@H:5]1[CH:10]2[CH2:11][CH2:12][N:7]([CH2:8][CH2:9]2)[CH2:6]1)(=O)C.[OH-].[Na+]>>[SH:4][C@@H:5]1[CH:10]2[CH2:11][CH2:12][N:7]([CH2:8][CH2:9]2)[CH2:6]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 53969335HCID 53969335, compound

Product 1

HCID 14154748HCID 14154748, compoundYield 45.8%

Procedure

(3R)-3-Mercaptoquinuclidine may be obtained in a manner similar to that described in Example 2, but starting with (3R)-3-(acetylthio)quinuclidine (32.5 g) and 10N aqueous sodium hydroxide solution (35 cc); (3R)-3-mercaptoquinuclidine (11.5 g) is obtained in the form of white crystals which melt at 45° C. and distil at 90° C. under 830 Pa (αD20 =+121°, C=1.1, methanol).

Sources & evidence

ORD record
ord-34fe213dde26457c82a973b151b3a0c5
Source dataset
uspto-grants-1989_01
Patent number
US04798827

Reaction notes

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