反应详情

Dimethyl 2-(2-amino-6-chloropurin-9-ylmethyl)succinate (8.00 g, 0.0244 mol) was dissolved in 200 ml of tert. butanol at 50° C., lithium borohydride (2.66 g, 0.122 mol) was added in portions, and the mixture was stirred for 1 h. Then 100 ml of water was added and the stirring was continued over-night, the inorganic salts were filtered off and the solution was evaporated to dryness in vacuum. The residue was found to contain 78 mole-% of 2-amino-6-tert.butoxy-9-[4-hydroxy-2(hydroxymethyl)butyl]purine together with the 6-chloro compound.

1. waitthe stirring was continued over-night
2. filtrationthe inorganic salts were filtered off
3. customthe solution was evaporated to dryness in vacuum