Potassium Carbonate → HCID 54484017, compound

Participants

Reaction Steps

2-Amino-6-chloropurine (3.37 g, 19.9 mmol), 4-bromo-2-hydroxymethylbutyric acid ethyl ester (4.49 g, 19.9 mmol) and anhydrous potassium carbonate (2.75 g, 19.9 mmol) were mixed with 50 ml of dimethylformamide and the mixture was stirred at room temperature during 92 hours. The mixture was then filtered and the filtrate evaporated. The residue was extracted with 3×50 ml chloroform and the combined extracts were evaporated. Flash chromatography (silica gel, chloroform-methanol 10:1) and two recrystallizations from water afforded 0.995 g of the 4-(2-amino-6-chloropurin-9-yl)-2-hydroxymethylbutyric acid ethyl ester.

Provenance & Evidence