HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 9-[4-Hydroxy-2-(hydroxymethyl)butyl]guanine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Benzyloxy-3-benzyloxymethylbutanol | HCID 562218 | — |
| Reactant | 9-(4-Hydroxy-2-(hydroxymethyl)butyl)guanine | HCID 135436455 | — |
| Catalyst | Ethanol | HCID 702 | — |
| Product | 9-[4-Hydroxy-2-(hydroxymethyl)butyl]guanine hydrochloride | HCID 136342838 | — |
Reaction Steps
9-[4-Hydroxy-2-(hydroxymethyl)butyl]guanine (46 mg; Example 1) was dissolved in 0.4 ml of 1M aqueous hydrochloric acid and the solution was lyophilized (0.1 mm Hg) over-night. The residue (53 mg, quantitive yield) was dissolved in a few drops of warm ethanol and precipitated with several volumes of tetrahydrofuran to yield a white, crystalline product. M.p. ~85° C. (d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04798833 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-2795d2dbb53c4c52a4dd1ffad878c628 |
| Source note | uspto-grants-1989_01 |