Potassium Carbonate → HCID 21278111, compound

Participants

Reaction Steps

A mixture of 1.61 g 2-amino-6-chloropurine (9.5 mmol) and 1.31 g finely ground anhydrous K2CO3 (9.5 mmol) in 50 ml of dry dimethylformamide (DMF) was kept at 100° C. for 5 min. and cooled. At 10° C. the crude 1-benzyloxy-2-benzyloxymethyl-4-chlorobut-2-ene in 25 ml of dry DMF was added with stirring during 4 h. After 2 days at room temperature the mixture was evaporated in vacuum, the residue was extracted with 2×25 ml of chloroform and the extract evaporated to dryness. Chromatography (silica gel, CHCl3 +MeOH 19+1) afforded 0.25 g (18%) of 4-(2-amino-6-chloropurin-9-yl)-1-benzyloxy-2-benzyloxymethyl-2-butene (TLC on silica gel, CHCl3 +MeOH 13+1 parts by volume Rf 0.62).

Provenance & Evidence