Sodium Hydroxide → HCID 23675389, compound

HRID 2291863Notes

Reaction equation

HRID 2291863 reaction equation
[CH3:1][C:2]([CH3:24])([CH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[N:19]=[C:20]([CH3:23])[S:21][CH:22]=2)=[CH:14][CH:13]=1)[C:3]([O:5]CC)=[O:4].[OH-].[Na+:26]>C(O)C>[CH3:1][C:2]([CH3:24])([CH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[N:19]=[C:20]([CH3:23])[S:21][CH:22]=2)=[CH:14][CH:13]=1)[C:3]([O-:5])=[O:4].[Na+:26]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14349173HCID 14349173, compound

Product 1

HCID 23675389HCID 23675389, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 5 ml of ethanol was dissolved 1.40 g of ethyl 2,2-dimethyl-5-[p-(2-methyl-4-thiazolyl)phenoxy]pentanoate obtained in EXAMPLE 5. The solution was added to an aqueous sodium hydroxide solution (0.4 g of sodium hydroxide in 5 ml of water) and the mixture refluxed for 10 hours. After cooling, the precipitated crystals was washed with water to obtain the desired product, sodium 2,2-dimethyl-5-[p-(2-methyl-4-thiazolyl)phenoxy]pentanoate as white crystals.

Workup

  1. temperaturethe mixture refluxed for 10 hours
  2. temperatureAfter cooling
  3. washthe precipitated crystals was washed with water

Sources & evidence

ORD record
ord-e7eca3b475f3409e91396460c61a55b1
Source dataset
uspto-grants-1989_01
Patent number
US04798838

Reaction notes

Loading…