Sodium Hydroxide → HCID 13422045, compound

HRID 2291871Notes

Reaction equation

HRID 2291871 reaction equation
C([O:3][C:4](=[O:30])[C:5]([CH3:29])([CH3:28])[CH2:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:27])[CH2:19][CH2:20][CH2:21][N:22]2[CH:26]=[CH:25][N:24]=[CH:23]2)=[CH:13][CH:12]=1)C.[OH-].[Na+]>CO>[N:22]1([CH2:21][CH2:20][CH2:19][C:18]([NH:17][C:14]2[CH:15]=[CH:16][C:11]([O:10][CH2:9][CH2:8][CH2:7][CH2:6][C:5]([CH3:28])([CH3:29])[C:4]([OH:30])=[O:3])=[CH:12][CH:13]=2)=[O:27])[CH:26]=[CH:25][N:24]=[CH:23]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13422038HCID 13422038, compound

Product 1

HCID 13422045HCID 13422045, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.0 g of Ethyl-6-[p-[4-(1-imidazolyl)-butyramido]-phenoxy]-2,2-dimethylhexanoate obtained from EXAMPLE 35 was stirred in 10 ml of methanol and 10 ml of 1N-aqueous sodium hydroxide solution at 40° C. for 16 hours. Ethanol was removed from the reaction mixture. The resulting mixture was washed with chloroform and then neutralized with 10 ml of 1N-aqueous hydrochloric acid solution. The precipitated crystals were collected by filtration, and recrystallized from 2-propanol to give 6-[p-[4-(1-imidazolyl)butyramido]phenoxy]-2,2-dimethyl hexanoic acid, as white crystals.

Workup

  1. customEthanol was removed from the reaction mixture
  2. washThe resulting mixture was washed with chloroform
  3. filtrationThe precipitated crystals were collected by filtration
  4. customrecrystallized from 2-propanol

Sources & evidence

ORD record
ord-3830ebf2671d436980d530eeec87c90f
Source dataset
uspto-grants-1989_01
Patent number
US04798838

Reaction notes

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