HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2291872Generated: October 30, 2026
4-Methoxyphenylacetic Acid → 4-Methoxyphenylacetyl chloride
https://huagongshe.com/reaction/2291872
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Methoxyphenylacetic Acid | HCID 7690 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 4-Methoxyphenylacetyl chloride | HCID 2734688 | 88% |
Reaction Steps
Thionyl chloride (200 ml) was added to 4-methoxyphenylacetic acid (78 g, 0.47 mole) followed by one drop of dimethylformamide. The reaction was heated at 65° C. for 4 hours and the solvent was removed under vacuum. The residue was distilled in vacuo (water aspirator) at 135° C. to give the product as a red oil (75.9 g, 88%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04798843 |
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| Source dataset | uspto-grants-1989_01 |
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| ORD ID | ord-10634a45803b44b5a2f52bfad6936b74 |
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| Source note | uspto-grants-1989_01 |
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