HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetyl chloride → HCID 10447619, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-[(2-Methoxyphenoxy)methyl]-1,3-thiazolidine | HCID 3025454 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 10447619 | HCID 10447619 | — |
Reaction Steps
A solution of 2-(o-methoxyphenoxymethyl)thiazolidine (100 g) in 1,2-dichloroethane (250 ml) cooled at 10° is heated, under stirring, with triethylamine (68 ml) and a solution of α-chloroacetylchloride (36.2 ml) in 1,2-dichloroethane (50 ml) is added dropwise. After 1 hour, the mixture is washed with water, dried on Na2SO4 and evaporated to dryness. Subsequent crystallization from propan-2-ol gives 3-α-chloroacetyl-2-(o-methoxyphenoxymethyl)thiazolidine m.p. 87°-88° C. (100 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04798898 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-0e386782220345c289cb4ab3d60af855 |
| Source note | uspto-grants-1989_01 |