Chloroacetyl chloride → HCID 20027606, compound

Participants

Reaction Steps

A solution of 2-(o-methoxyphenoxymethyl)thiazolidine (15 g) in acetone (75 ml), cooled at 10° C., under stirring is added with triethylamine (10.5 ml) and dropwise with a solution of α-chloroacetylchloride (5.8 ml) in acetone (15 ml). After 2 hours the mixture is added with potassium thioacetate (35.4 g) and stirring is continued for 2 hours, the mixture is poured in ice and water (250 ml) and the precipitate is filtered and crystallized from EtOH to give 2-(o-methoxyphenoxy)methyl-3-acetylthioacetylthiazolidine (19.8 g, 87% yield) m.p. 89°-91° C.

Provenance & Evidence