Sodium Chloride → HCID 20144429, compound

Participants

Reaction Conditions

Reaction Steps

3.90 g of methyl 3-cyano-1-(2-propynyl)-1H-pyrrole-4-carboxylate, 35 ml of tetrahydrofuran, 11 ml of water and 1.556 g of lithium borohydride were mixed together and stirred for 3 hours 30 minutes at 20° C. The reaction mixture was poured into a saturated aqueous solution of sodium chloride with stirring and was extracted with ethyl acetate. The extracts were concentrated to dryness by distilling under reduced pressure and the residue was chromatographed over silica. Elution with a mixture of hexane and ethyl acetate (4-6) yielded 1.33 g of of 4-hydroxymethyl-1-(2-propynyl)-1H-pyrrole-3-carbonitrile melting at 95° C.

Provenance & Evidence