Hydrochloric Acid → HCID 13934064, compound

Participants

Reaction Conditions

Reaction Steps

To 70 ml of pyridine were added 5.24 g of N-hexyl-N-(2-hydroxyethyl)-5-isoquinolinesulfonamide and 3.39 g of p-toluenesulfonyl chloride. The resulting mixture was stirred at 60° C. for 4 hours. Then, the pyridine was removed under reduced pressure to obtain an oily residue. To the residue were added 50 ml of chloroform and 20 ml of an aqueous hydrochloric acid solution having a pH of 2, and the chloroform layer was dried with anhydrous magnesium sulfate. Then, the chloroform was removed under reduced pressure to obtain a residue. The residue thus obtained was subjected to purification by silica gel column chromatography (Wacogel C-200, 100 g; solvent: a 3% methanol solution in chloroform) to obtain 2.60 g of N-hexyl-N-(2-p-toluenesulfonyloxyethyl)-5-isoquinolinesulfonamide.

Provenance & Evidence