Ammonia → HCID 13934065, compound

Participants

Reaction Conditions

Reaction Steps

To 2.34 g of the thus obtained N-hexyl-N-(2-p-toluenesulfonyloxyethyl)-5-isoquinolinesulfonamide was added 40 ml of an ethanol solution containing 4 g of ammonia, and the mixture was heated at 90° C. for 48 hours in a pressure vessel. Then, the solvent was removed under reduced pressure to obtain a residue. The residue thus obtained was subjected to purification by silica gel column chromatography (Wacogel C-200, 100 g; solvent: a 3% methanol solution in chloroform) to obtain 1.34 g of N-hexyl-N-(2-aminoethyl)-5-isoquinolinesulfonamide [Compound (4)]. Compound (4) was analyzed to give the following data.

Provenance & Evidence