Ammonium Acetate → HCID 14326747, compound

Participants

Reaction Steps

Substantially the same procedures as in Example 13 were repeated except that 5.84 g to 1-(5-isoquinolinesulfonyl)-3-hydroxypiperidine was used in place of 5.84 g of 1-(5-isoquinolinesulfonyl)-4-hydroxypiperidine and that 2.9 g of the thus obtained 1-(5-isoquinolinesulfonyl)-3-piperidone was reacted in methanol with 2.31 g of ammonium acetate and 0.63 g of sodium cyanoborohydride at 20° C. for 24 hours. There was obtained 2.37 g of 1-(5-isoquinolinesulfonyl)-3-aminopiperidine [Compound(63)]. Compound (63) was analyzed to give the following data.

Provenance & Evidence