Ammonia → HCID 14326799, compound

Participants

Reaction Conditions

Reaction Steps

To 2.37 g of the thus obtained N-hexyl-N-(1-p-toluenesulfonyloxymethylpentyl)-5-isoquinolinesulfonamide was added 40 ml of an ethanol solution containing 4 g of ammonia, and the mixture was heated in a pressure vessel at 100° C. for 13 hours. Then, the solvent was removed under reduced pressure to obtain a residue. The residue thus obtained was subjected to purification by silica gel column chromatography (Wacogel C-200, solvent: a 5% methanol solution in chloroform) to obtain 0.70 g of N-(1-aminomethylpentyl)-N-hexyl-5-isoquinolinesulfonamide [Compound (19)]. Compound (19) was analyzed to give the following data.

Provenance & Evidence