1-Octanol → HCID 527521, compound

Participants

Reaction Steps

Racemic 2-chloropropionate octyl ester was prepared by reacting 130 gm (1.0 mole) of n-octanol with 127 gm (1.0 mole) of 2-chloropropionyl chloride in 240 ml of pyridine and 50 ml of tetrahydrofuran. The reaction was carried out for 24 hours after which the solution was washed with 500 ml of: (1) 1N HCl, 2) saturated solution of NaHCO3, and (3) saturated solution of NaCl. The organic phase was finally dried over MgSO4. The total weight of 2-chloropropionate octyl ester obtained was 210 gm (0.96 mole).

Provenance & Evidence