Imidazole → HCID 70351161, compound

Participants

Reaction Steps

To 0.08 moles of imidazole in 70 ml of acetonitrile, at the temperature of 10 C., 0.02 moles of thionylchloride are added, followed by 1 hour rest, and then 0.02 moles of (benzofuran-2-yl)phenylmethanol are added in 20 ml of acetonitrile. The reaction admixture is kept 24 hours at ambient temperature and then concentrated to dryness. The residue is taken up with ethylether, washed first with 2% sodium hydrate solution and then with water: the hydrochloride is obtained from the ethereal solutions using 5% hydrochloric acid, then an oil is obtained by alkalinization with 5% NaOH, which is extracted with ethylether. The ethereal extract is washed, made anhydrous and saturated with gaseous HCl: the precipitate thus obtained is crystallized from isopropanol: m.p. 205°-207° C. (dec.).

Provenance & Evidence