p-METHYLACETOPHENONE → HCID 54228629, compound

Participants

Reaction Steps

To a solution of 10.1 g (0.18 mole) of potassium hydroxide in 2.18 L of water was added 176.4 g (1.32 mole) of 4-methylacetophenone and 50 g (0.53 mole) of pyrrole-2-carboxaldehyde. The mixture was heated to 40°-45° C. with mechanical stirring under a nitrogen atmosphere overnight. The solid precipitate was filtered, washed with water and 2-propanol, and air dried to give 42.1 g (38% yield) of the title compound as a solid, mp 158.5°-159.5° C.

Provenance & Evidence