3-Methylpyridazine → HCID 13672425, compound

HRID 2292016Notes

Reaction equation

HRID 2292016 reaction equation
[CH3:1][C:2]1[N:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[Cl:8][C:9]([Cl:16])([Cl:15])[CH2:10][O:11][C:12](Cl)=[O:13].[CH3:17][C:18]1[NH:19][C:20](=[O:24])[CH2:21][S:22][CH:23]=1>>[CH3:17][C:18]1[NH:19][C:20](=[O:24])[CH2:21][S:22][C:23]=1[CH:7]1[CH:6]=[CH:5][N:4]([C:12]([O:11][CH2:10][C:9]([Cl:16])([Cl:15])[Cl:8])=[O:13])[N:3]=[C:2]1[CH3:1]

Participants

4

Reactant 3

HCID 742083-MethylpyridazineHCID 870632,2,2-Trichloroethyl chloroformateHCID 2900175-Methyl-2h-1,4-thiazin-3(4h)-one

Product 1

HCID 13672425HCID 13672425, compoundYield 10%

Procedure

A mixture of 3-methylpyridazine (1.82 ml), 2,2,2-trichloroethylchloroformate (3.44 ml) and 5-methyl-2H-1,4-thiazin-3(4H)-one (1.29 g) was treated in the same manner as described in Example 2 (i) to give the titled compound (0.4 g, yield 10%) as white crystals. n-Hexane-ethyl acetate (=3:2) was used as a developing eluant.

Workup

  1. additionwas treated in the same manner

Sources & evidence

ORD record
ord-98974a7c2151427bacf9325efd18440b
Source dataset
uspto-grants-1989_01
Patent number
US04800201

Reaction notes

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