反应详情

Ammonium carbonate (0.6 g) was added to a solution of 2-(3-chlorobenzoyloxy)-5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one (0.4 g) in acetonitrile (20 ml). The mixture was stirred at ambient temperature for 3 days, was filtered and the filtrate was evaporated to dryness. The residue was chromatographed on silica gel (Wakogel C-200) column, using chloroform-methanol (=20:1) as an eluant to give the titled compound (0.1 g, yield 40.7%).

1. filtrationwas filtered
2. customthe filtrate was evaporated to dryness
3. customThe residue was chromatographed on silica gel (Wakogel C-200) column