Ammonium Carbonate → HCID 13936020, compound

HRID 2292031Notes

Reaction equation

HRID 2292031 reaction equation
C(=O)([O-])[O-].[NH4+:5].[NH4+].ClC1C=C(C=CC=1)C(O[CH:14]1[C:19](=[O:20])[NH:18][C:17]([CH3:21])=[C:16]([C:22]2[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=2)[S:15]1)=O>C(#N)C>[NH2:5][CH:14]1[C:19](=[O:20])[NH:18][C:17]([CH3:21])=[C:16]([C:22]2[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=2)[S:15]1

Participants

4

Reactant 2

HCID 517111Ammonium CarbonateHCID 139360302-(3-chlorobenzoyloxy)-5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one

Product 1

HCID 13936020HCID 13936020, compoundYield 40.8%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Ammonium carbonate (0.6 g) was added to a solution of 2-(3-chlorobenzoyloxy)-5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one (0.4 g) in acetonitrile (20 ml). The mixture was stirred at ambient temperature for 3 days, was filtered and the filtrate was evaporated to dryness. The residue was chromatographed on silica gel (Wakogel C-200) column, using chloroform-methanol (=20:1) as an eluant to give the titled compound (0.1 g, yield 40.7%).

Workup

  1. filtrationwas filtered
  2. customthe filtrate was evaporated to dryness
  3. customThe residue was chromatographed on silica gel (Wakogel C-200) column

Sources & evidence

ORD record
ord-04e9da30a50d44d6990c32c2fffe34ed
Source dataset
uspto-grants-1989_01
Patent number
US04800201

Reaction notes

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