Water → HCID 13936026, compound

HRID 2292036Notes

Reaction equation

HRID 2292036 reaction equation
ClC1C=C(C=CC=1)C([O:7][CH:8]1[C:13](=[O:14])[NH:12][C:11]([CH3:15])=[C:10]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[S:9]1)=O.O>CC(C)=O>[OH:7][CH:8]1[C:13](=[O:14])[NH:12][C:11]([CH3:15])=[C:10]([C:16]2[CH:17]=[CH:18][N:19]=[CH:20][CH:21]=2)[S:9]1

Participants

4

Reactant 2

HCID 962WaterHCID 139360302-(3-chlorobenzoyloxy)-5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one

Product 1

HCID 13936026HCID 13936026, compoundYield 19.1%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
70 °C

Procedure

2-(3-Chlorobenzoyloxy)-5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one (1.37 g) and water (1 ml) were dissolved in acetone (20 ml) and the mixture was stirred at 70° C. for 44 hours. The mixture was chromatographed on silica gel (Wakogel C-200) column, using chloroform-methanol (=30:1) as an eluant to give the titled compound (0.16 g, yield 19.1%) as red needles.

Workup

  1. customThe mixture was chromatographed on silica gel (Wakogel C-200) column

Sources & evidence

ORD record
ord-8660305a14e94d238bc41e0a5ee276c2
Source dataset
uspto-grants-1989_01
Patent number
US04800201

Reaction notes

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