Boron tribromide → HCID 14257794, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 7-methoxy-3,5,6-trimethylbenzofuran-2-carboxylate (97.2 g, 0.37 mole) (from Step 2) in dichloromethane (1 L) cooled to -78° C., was added a solution of BBr3 (1.1 L, 1 M in dichloromethane). The reaction was warmed to -5° C. for and left for 15 mins. Quenching with 25% NH4OAc buffer, extraction with EtOAc and drying (Na2SO4), followed by removal of solvent, afforded the product which was used as such for the following step.

Provenance & Evidence