Ethanethiol → HCID 14307643, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 2-(4-methoxybenzyl)-3-methyl-5-propyl-4,7-benzofurandione (from Preparation 28) (0.988 g, 3.05 mmol) in MeOH (23 mL) was added ethanethiol (2.5 mL). After a few minutes, the yellow quinone passed into solution giving a reddish colour. The reaction was cooled to 0° C. and solid FeCl3 (2.5g) was added. The reaction was quenched 10% HCl and extraction with CH2Cl2 afforded the crude product which was chromatographed on silica gel (5% EtOAc/hexane) to yield the title compound.

Provenance & Evidence