6-Methyl-2-pyridinecarboxaldehyde → HCID 86742683, compound

HRID 2292072Notes

Reaction equation

HRID 2292072 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([CH:8]=O)[CH:5]=[CH:4][CH:3]=1.[CH:10]([C:12]1[CH:17]=[CH:16][C:15]([C@@H:18]([NH2:26])[CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:14][CH:13]=1)=[CH2:11]>C1C=CC=CC=1>[CH:10]([C:12]1[CH:17]=[CH:16][C:15]([C@@H:18]([N:26]=[CH:8][C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([CH3:1])[N:7]=2)[CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:14][CH:13]=1)=[CH2:11]

Participants

4

Reactant 2

HCID 707376-Methyl-2-pyridinecarboxaldehydeHCID 53967271HCID 53967271, compound

Product 1

HCID 86742683HCID 86742683, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

A solution of 0.54 g (4.5 mmol) of 6-methyl-pyridine-2-carbaldehyde, 1.0 g (4.5 mmol) of (S)-1-(4-vinylphenyl)-2-phenyl-ethylamine and 10 ml of benzene is evaporated down at room temperature and under about 3 kPa. A further 10 ml of benzene are added in order to distill off residual water of reaction together with benzene under about 3 kPa. The process is repeated twice more.

Workup

  1. distillationto distill off
  2. customresidual water of reaction together with benzene under about 3 kPa

Sources & evidence

ORD record
ord-977319a3f2c74b88a10631f26d1a0658
Source dataset
uspto-grants-1989_01
Patent number
US04800224

Reaction notes

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