HCID 21276951, compound → HCID 21276950, compound

Participants

Reaction Conditions

Reaction Steps

Palladium on carbon (0.10 g; 5%) was added to a solution of 3-benzyloxycarbonyl-5-(N-t-butylcarbamoyl)-4-(2-chlorophenyl)-6-methyl-2-[2-(2-methylbenzimidazol-1-yl)ethoxymethyl]-1,4-dihydropyridine (0.143 g, 0.23 mmol) in ethanol (8 ml) and the mixture stirred under hydrogen (1 bar) at 28° C. for 5 hours. The catalyst was removed by filtration, the solvent evaporated and the residue triturated with hot diethyl ether to yield the title product as a white solid (0.097 g, 79%), m.p. 187°-188° C. Found: C,62.77; H, 6.35; N, 10.09. C29H33ClN4.H2O requires C, 63.17; H, 5.96; N, 10.09%.

Provenance & Evidence