Isopropylamine → HCID 21276962, compound

Participants

Reaction Conditions

Reaction Steps

Dimethylaminopyridine (0.026 g, 0.21 mmol) and N,N'-dicyclohexylcarbodiimide (0.048 g, 0.23 mmol) were added to a stirred suspension of 5-(N-t-butylcarbamoyl)-3-carboxy-4-(2-chlorophenyl)-6-methyl-2-[2-(2-methylbenzimidazol-1-yl)ethoxymethyl]-1,4-dihydropyridine (0.107 g, 0.2 mmol) in dry dichloromethane (2 ml). The mixture was stirred for 16 hours at 24° C. and then treated with isopropylamine (0.17 ml, 2 mmol). The mixture was stirred for a further 3 hours and the solvent then evaporated and the residue chromatographed on silica gel, eluting with a mixture of methanol and ethyl acetate (1:9) to afford the title compound as a colourless oil which crystallised on standing (0.08 g, 68%), m.p. 191-193° C. Found: C, 66.18; H, 7.38; N, 11.72. C32H40ClN5O3 requires: C, 66.48; H, 6.97; N, 12.11%.

Provenance & Evidence