HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → Ethyl (2-chloro-6-oxocyclohex-1-en-1-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 12355684 | HCID 12355684 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl (2-chloro-6-oxocyclohex-1-en-1-yl)acetate | HCID 14330442 | — |
Reaction Steps
A slurry of ethyl α-(2,6-dioxocyclohexyl)acetate hydrate (1.53 kg) in methylene chloride (7.7L) is brought to reflux and then thionyl chloride (1.80 kg) is added dropwise over a period of 1.75 hours. The solution is refluxed for 3 hours and then evaporated in vacuo to yield an oil which is distilled to give ethyl α-(2-chloro-6-oxocyclohex-1-enyl)acetate as a yellow oil, bp 115°-125°/0.2 mm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04801605 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-852f04908fb64e259b45c1c4b91b9d43 |
| Source note | uspto-grants-1989_01 |