HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Benzoyl-2(S)-trifluoroacetamidobutyric acid → 5-Phenyl-2(S)-trifluoroacetamidopentanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Benzoyl-2(S)-trifluoroacetamidobutyric acid | HCID 14390810 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-Phenyl-2(S)-trifluoroacetamidopentanoic acid | HCID 14390812 | 84.3% |
Reaction Steps
Reduce the product of Step 1 (9.7 g) with Pearlman's catalyst (3.5 g) in EtOAc (75 ml) and ethanol (25 ml) at 50 psi H2 for 3 hours. Filter, concentrate and wash the resultant residue with 3:1 hexane:diethyl ether to give the title compound (7.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04801609 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-f38812ad458442d299f1c660c3f8e74f |
| Source note | uspto-grants-1989_01 |