Water → HCID 14010380, compound

HRID 2292179Notes

Reaction equation

HRID 2292179 reaction equation
[OH:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[CH3:16][C:17]([CH3:22])([CH3:21])[C:18](Cl)=[O:19].O>N1C=CC=CC=1>[C:18]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:14][CH:15]=1)(=[O:19])[C:17]([CH3:22])([CH3:21])[CH3:16]

Participants

5

Reactant 3

HCID 962WaterHCID 143474-HydroxybenzophenoneHCID 62493Pivaloyl chloride

Product 1

HCID 14010380HCID 14010380, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent2×

Procedure

A solution of 2.0 g (1 mmol) of 4-hydroxybenzophenone and 1.25 g (1.5 mmol) of trimethylacetyl chloride in 30 ml of pyridine was heated to 50° C. for 2 h. The reaction mixture was stripped of most of the pyridine and then slurried into water. The crude product obtained by filtration was air-dried and recrystallized from ethanol. The first crop (2.35 g, 79.9%, M.P.≅100°-102° C.) was used for analysis and biological evaluation.

Sources & evidence

ORD record
ord-8f98b987d2cb46e7babafbaaa6cda176
Source dataset
uspto-grants-1989_01
Patent number
US04801610

Reaction notes

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