Pivaloyl chloride → 4,4'-BIS(TRIMETHYLACETOXY)BENZOPHENONE

Participants

Reaction Steps

A solution of 10 g of 4,4' dihydroxybenzophenone in pyridine (40ml) was treated with trimethylacetyl chloride and refluxed for 5 hours. The resultant solution was concentrated under reduced pressure and ETOAc added. The organic layer was washed with H2O, 5% aq. K2CO3, 1% aq. NaOH and dried over MgSO4 and concentrated to give approximately 13 g of a beige solid which was further chromatographed using 7/93 ethyl acetate-toluene to yield 2.83 g (20%) of the monoester (a) and 3.42 g (19%) (b) of the title compound; M.P.=166°-167° C.

Provenance & Evidence