Dimethyl Sulfate → HCID 21277003, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of three grams of (2,4-dihydroxy-3-propylphenyl)(2-hydroxyphenyl)methanone in 50 ml of 2-butanone were added 3.04 g of potassium carbonate and 0.52 ml of dimethyl sulfate. The mixture was stirred at reflux temperature overnight, cooled to 25° C., and poured into diethyl ether/water. The layers were separated. The organic layer was washed twice with water, once with a saturated sodium chloride solution, dried over magnesium sulfate, and concentrated providing 2.94 g of the desired title product as an oil.

Provenance & Evidence