Methyl iodide → HCID 21277244, compound

Participants

Reaction Steps

A two-phase mixture of 35.1 g (0.15 mole) of 4-amino-3-methylthio-6-phenyl-4H-1,2,4-triazin-5-one, 24.4 ml (0.375 mole) of methyl iodide, 5 g of tetrabutylammonium bromide, 200 ml of toluene and 60 ml of a 50% solution of sodium hydroxide is efficiently stirred for 2 hours, the temperature rising from 20° to 40° C. The organic phase is separated and filtered over silica gel. Evaporation of the filtrate yields 25.1 g (67.5% of theory) of 4-methylamino-3-methylthio-6-phenyl-4H-1,2,4-triazin-5-one which melts at 119°-120° C.

Provenance & Evidence