Methylamine → HCID 21277253, compound

Participants

Reaction Steps

10.0 g (0.04 mole) of 4-methylamino-3-methylthio-6-phenyl-4H-1,2,4-triazin-5-one, 1.6 g (0.05 mole) of methylamine and 50 ml of isopropanol are heated for 4 hours in a bomb tube to 155° C. The resultant clear orange solution is concentrated by evaporation and the residue is chromatographed through silica gel eluted with a 95:5 mixture of methylene chloride/ether. The eluate is concentrated by evaporation and the residue is washed with petroleum ether, affording 8.1 g (88% of theory) of 3,4-bis(methylamino)-6-phenyl-4H-1,2,4-triazin-5-one with a melting point of 150°-151° C.

Provenance & Evidence